HSP77

HSP77, also known as heat shock protein 77, is a member of the heat shock protein family. These proteins are molecular chaperones that play a crucial role in cellular protein folding, assembly, and degradation. HSP77 specifically is involved in the maturation of certain protein complexes, including those found in the endoplasmic reticulum. It assists in the proper folding of newly synthesized proteins and helps prevent their aggregation, which can be toxic to the cell.

The expression of HSP77, like other heat shock proteins, is typically upregulated in response to cellular stress. This stress can include elevated temperatures, oxidative damage, or exposure to toxins. By increasing HSP77 levels, cells can better cope with these challenging conditions, maintaining protein homeostasis and ultimately improving their survival. Research into HSP77 has explored its involvement in various cellular processes, including protein trafficking and its potential role in disease pathogenesis, though much of this remains an active area of scientific investigation.