HPMCAS

HPMCAS, or hydroxypropyl methylcellulose acetate succinate, is a semi-synthetic, water-soluble polymer derived from cellulose. It is primarily used as an excipient in pharmaceutical formulations, particularly for oral drug delivery systems. The compound combines characteristics of cellulose ethers with those of cellulose esters, providing unique properties such as pH-dependent solubility and film-forming capabilities.

HPMCAS is classified into different grades based on its degree of substitution and molecular weight, which influence its solubility profile and functional performance. It is commonly employed in enteric coatings and matrix systems to enhance drug stability, control release rates, and improve bioavailability. The polymer dissolves in the small intestine due to its pH-sensitive nature, making it suitable for protecting acid-sensitive drugs from gastric degradation.

In addition to pharmaceutical applications, HPMCAS is studied for its potential use in controlled-release formulations, such as sustained-release tablets and capsules. Its biocompatibility and non-toxic nature further contribute to its widespread adoption in drug development. The material is also explored in biomedical research for applications like tissue engineering scaffolds and drug delivery matrices.

Manufactured through chemical modification of cellulose, HPMCAS is produced under strict quality control to ensure consistency and purity. It is typically supplied as a fine powder and must be handled in accordance with good manufacturing practices to maintain its efficacy. While generally recognized as safe for pharmaceutical use, proper formulation and testing are essential to optimize its performance in drug products.