HOCH2CF3

HOCH2CF3, also known as 2,2,2-trifluoroethanol or TFE, is a chemical compound with the formula CF3CH2OH. It is a colorless liquid at room temperature with a distinctive odor. TFE is miscible with water and many organic solvents, making it a versatile solvent in various chemical applications.

One of the notable properties of TFE is its ability to stabilize secondary structures in peptides and proteins, such as alpha-helices. This makes it a valuable tool in biochemistry and biophysics for studying protein folding and conformation. TFE is also employed as a solvent in organic synthesis, particularly for reactions involving polar compounds. Its strong hydrogen-bonding capabilities and its relatively low nucleophilicity contribute to its effectiveness in these roles.

Due to its unique solvent properties, TFE finds use in analytical chemistry, including chromatography. It can be used as a mobile phase component or as a solvent for sample preparation, aiding in the separation and analysis of complex mixtures. The compound is also investigated for its potential in other fields, including materials science and as a component in specialized formulations. However, it is important to note that TFE is a volatile and flammable substance, and appropriate safety precautions should be taken when handling it. Its environmental impact and toxicity are also considerations in its industrial use and disposal.