Glucocorticoidinduced

Glucocorticoid-induced refers to conditions or effects caused by the prolonged use or overuse of glucocorticoids, a class of steroid hormones. These hormones are naturally produced by the adrenal glands and play vital roles in metabolism, immune response, and stress management. When administered exogenously, typically as medications like prednisone or dexamethasone, they are powerful anti-inflammatory and immunosuppressive agents used to treat a wide range of conditions including asthma, autoimmune diseases, and allergies.

However, long-term or high-dose glucocorticoid therapy can lead to a variety of adverse effects, collectively termed glucocorticoid-induced conditions. Common examples include Cushing's syndrome, characterized by symptoms such as weight gain, moon face, and skin changes. Osteoporosis, a decrease in bone density leading to increased fracture risk, is another significant concern. Glucocorticoid-induced diabetes mellitus can develop or existing diabetes can worsen. Other potential side effects include mood changes, impaired wound healing, increased susceptibility to infections, and adrenal suppression, where the body's natural production of cortisol is reduced. The management of glucocorticoid-induced conditions involves careful monitoring, dose adjustments, and sometimes specific treatments to mitigate these side effects.