Glipt

Glipt refers to a class of medications used to treat type 2 diabetes. These drugs are also known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Gliptins work by increasing the levels of incretin hormones in the body. Incretins are hormones that stimulate the pancreas to produce insulin and reduce the amount of glucose produced by the liver. DPP-4 is an enzyme that breaks down incretin hormones, so gliptins inhibit this enzyme, allowing incretins to remain active for longer. This leads to improved blood glucose control.

Common gliptins include sitagliptin, saxagliptin, linagliptin, and alogliptin. They are typically taken orally, either alone or in combination with other diabetes medications such as metformin. Gliptins are generally well-tolerated, with common side effects including headache, nasopharyngitis, and upper respiratory tract infections. Serious side effects, though rare, can include pancreatitis and severe joint pain. Gliptins are not typically prescribed for type 1 diabetes or diabetic ketoacidosis. Their effectiveness and safety profile make them a valuable option for managing type 2 diabetes in many individuals.