Glikoleptide

Glikoleptide is a class of antibiotics that inhibit bacterial cell wall synthesis. They are composed of a glycopeptide backbone, which is a peptide chain with sugar molecules attached, and a depsipeptide side chain, which is a peptide chain with ester bonds. Glikoleptides are effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They work by binding to the D-alanyl-D-alanine (D-Ala-D-Ala) residues in the bacterial cell wall, preventing the cross-linking of peptidoglycan chains and leading to cell lysis. Glikoleptides are typically administered intravenously and have a relatively short half-life. They are often used in combination with other antibiotics to treat severe infections. Common examples of glikoleptides include vancomycin and teicoplanin. However, the use of glikoleptides has been declining due to the rise of antibiotic resistance, and they are generally considered a last-resort treatment option.