GeneCards

GeneCards is a comprehensive, gene-centric database of human genes designed to provide concise integrated information on their functions, expression, and roles in disease. It aggregates data from public resources to offer a single-entry profile for each gene.

Each gene card assembles data from multiple domains, including gene nomenclature and location, transcripts and proteins, function and pathways, expression patterns across tissues, orthologs and paralogs, regulatory elements, genetic variants, and disease and pharmacological associations. The database links to external resources such as NCBI, Ensembl, UniProt, RefSeq, OMIM, ClinVar, DisGeNET, GTEx, and pathway and protein-interaction databases.

GeneCards reports typically present a central summary with sections for Related Genes, Proteins, Expression, Variants, Diseases, Drugs, and Pathways, along with cross-references to additional resources. The resource is widely used for gene prioritization, interpretation of experimental results, and literature triage in biomedical research.

Access is provided via the GeneCards website (genecards.org), where users can search by gene symbol, alias, disease, or genomic coordinates and navigate to individual gene cards. The database aims to keep information current by integrating data from diverse sources and updating entries as new data arrive.