GateControlModell
Gate Control Model, also known as the Gate Control Theory of Pain, is a neurophysiological framework proposed by Ronald Melzack and Patrick Wall in 1965 to explain how pain is perceived. The theory posits that the transmission of nociceptive signals from the body to the brain is governed by a gating mechanism in the dorsal horn of the spinal cord, rather than being a direct result of nociceptor activity alone. The gate can either amplify or suppress signals reaching higher brain centers, thereby shaping the conscious experience of pain.
Mechanistically, the model emphasizes interaction among different nerve fibers and interneurons. Large-diameter Aβ fibers, which convey
Implications of the model have been broad. It helped explain why rubbing a painful area or applying