GTPbindende

GTPbindende refers to proteins that bind to guanosine triphosphate (GTP). These proteins, often referred to as GTPases, are crucial regulators of a vast array of cellular processes. They function as molecular switches, cycling between an active state bound to GTP and an inactive state bound to guanosine diphosphate (GDP). This GTP/GDP binding cycle is typically mediated by intrinsic or regulator-activated hydrolysis of GTP to GDP. Key cellular functions regulated by GTPases include signal transduction, protein synthesis, vesicle transport, cell division, and cytoskeletal organization. There are numerous families of GTPases, each with specific roles. For example, Ras GTPases are involved in growth factor signaling, while Rho GTPases regulate the actin cytoskeleton. Rab GTPases are essential for vesicular trafficking, and Arf GTPases are involved in membrane trafficking and organelle assembly. The precise control over GTPase activity is vital for cellular health, and dysregulation of these proteins is implicated in various diseases, including cancer and developmental disorders.