GPCRn

GPCRn is a hypothetical class of G protein-coupled receptors (GPCRs). GPCRs are a large family of cell surface receptors that play a critical role in signal transduction. They are involved in a vast array of physiological processes, including sensory perception, neurotransmission, hormone regulation, and immune responses.

The defining characteristic of GPCRs is their structure, which consists of seven transmembrane alpha-helices. Ligand binding to the extracellular domain of a GPCR triggers a conformational change that activates intracellular G proteins. These G proteins then mediate downstream signaling pathways, leading to various cellular responses.

The nomenclature "GPCRn" suggests a potential future or theoretical categorization within the GPCR superfamily. It could represent a newly discovered subfamily, a class defined by specific structural or functional properties not yet fully elucidated, or a placeholder for receptors that share certain characteristics with known GPCRs but lack precise classification. Research into GPCRs is ongoing, and new members or subclasses are continually being identified and characterized. The discovery and understanding of such novel GPCR families are crucial for developing targeted therapies for a wide range of diseases.