GPCRdesensitisaatioon
GPCR desensitization refers to the process by which G protein-coupled receptors (GPCRs) become less responsive to stimulation. This is a critical regulatory mechanism that prevents overstimulation of cellular pathways and maintains cellular homeostasis. Desensitization can occur through several mechanisms, primarily involving changes to the receptor itself or its downstream signaling components.
One common mechanism is receptor phosphorylation. Upon prolonged activation by a ligand, GPCRs can be phosphorylated
Internalization is another key aspect of GPCR desensitization. Receptors are often sequestered into intracellular vesicles, a
Desensitization can also involve changes in the expression levels of receptors or their signaling partners. Chronic
GPCR desensitization is vital for a wide range of physiological processes, including neurotransmission, hormone signaling, and