GLUT1D

GLUT1D is a term that has appeared in some biological databases and discussions as a possible designation for a variant or paralog within the glucose transporter family. Unlike the well-established GLUT1 protein, which is encoded by the SLC2A1 gene and extensively characterized, GLUT1D is not recognized as a defined, standalone human gene in major public catalogs. As a result, there is no widely accepted set of experimental data confirming its existence, sequence, expression pattern, or physiological role in humans.

Nomenclature and status in the literature are inconsistent. In many resources, GLUT1D may be mentioned only as a tentative label or as an alias in comparative genomics studies, and it is not routinely cited as a distinct transporter with proven function. Because of this lack of consensus, the term does not correspond to a clearly defined protein with established structure or regulatory characteristics.

If a GLUT1D-like protein were to exist, it would be expected to belong to the major facilitator superfamily of transporters and to share the characteristic 12 transmembrane helices of the GLUT family, potentially mediating facilitative transport of glucose and related hexoses. However, without experimental validation, specific substrate preferences, tissue distribution, regulatory mechanisms, and physiological roles remain speculative.

Clinical relevance: no robust evidence currently links GLUT1D to diseases or therapeutic contexts, given the absence of confirmed data. Researchers typically focus on GLUT1/SLC2A1 for insights into glucose transport and associated disorders.

See also: GLUT1, SLC2A1, glucose transporter family.