GDI1

GDI1 refers to Guanine nucleotide Dissociation Inhibitor 1. It is a protein encoded by the GDI1 gene in humans. This gene is located on the X chromosome. GDI1 plays a crucial role in the regulation of small GTPases, particularly those belonging to the Rho family. These GTPases are involved in a wide range of cellular processes, including cell motility, cell cycle progression, and signal transduction. GDI1 acts by binding to the GDP-bound form of these GTPases, preventing their dissociation from GDP and their subsequent activation by GTP. This inhibitory action helps to maintain the GTPases in an inactive state until specific cellular signals are received. Dysregulation of GDI1 has been implicated in various neurological disorders, including intellectual disability and certain forms of autism spectrum disorder, due to its essential role in neuronal development and function. Research into GDI1 continues to explore its precise mechanisms of action and its therapeutic potential for related conditions.