GCN5PCAF
GCN5PCAF refers to the related histone acetyltransferase enzymes GCN5 and PCAF, encoded by the human KAT2A and KAT2B genes. They are the catalytic subunits of SAGA-type coactivator complexes and are conserved from yeast to humans. In mammalian cells, GCN5 and PCAF can function as mutually exclusive components within SAGA-like assemblies, supporting transcriptional activation through chromatin modification.
GCN5 and PCAF belong to the GNAT (Gcn5-related N-acetyltransferase) family and use acetyl-CoA to transfer acetyl
Regulation of GCN5 and PCAF occurs at multiple levels, including expression of KAT2A and KAT2B, interactions
Dysregulation of GCN5PCAF has been associated with diseases, notably cancer, where altered acetylation patterns can affect