Fibronektinu

Fibronektinu is a glycoprotein found in the extracellular matrix of animals. It plays a crucial role in cell adhesion, migration, growth, and wound healing. Fibronektinu is a large molecule composed of two subunits linked by disulfide bonds. It has multiple binding sites that allow it to interact with various molecules, including cell surface receptors like integrins, collagen, fibrin, and heparin.

There are two main isoforms of fibronektinu: cellular fibronektinu and plasma fibronektinu. Cellular fibronektinu is synthesized by fibroblasts and other cell types and is deposited into the extracellular matrix. Plasma fibronektinu is synthesized by hepatocytes and circulates in the blood plasma. Both isoforms share a similar structure and many functions, but plasma fibronektinu is particularly important in blood clotting and wound healing.

The multi-domain structure of fibronektinu enables it to mediate a wide range of biological processes. For example, its interaction with integrins on the cell surface initiates signaling pathways that influence cell behavior. This adhesion is vital for tissue development and repair. In wound healing, fibronektinu acts as a scaffold, guiding migrating cells to the injury site and promoting the formation of new tissue. Dysregulation of fibronektinu function has been implicated in various diseases, including cancer metastasis and fibrotic disorders.