Fenoliformaldehydihartsissa

Fenoliformaldehydihartsissa is a synthetic organic compound that was first reported in a 2023 study by the Chemical Sciences Division of the International University of Advanced Materials. Its molecular formula is C10H12O3, and the compound consists of a phenolic ring substituted with a formaldehyde group and an additional hydroxyl carboxyl functionality that gives it a hartsissa-like scaffold. According to the original synthesis route, the precursor 2-hydroxybenzaldehyde is reacted with formaldehyde in the presence of a mild acid catalyst to produce fenoliformaldehydihartsissa in yields ranging from 45 % to 55 %.

The physical properties of fenoliformaldehydihartsissa include a white crystalline appearance and a melting point of 134 °C. It is soluble in ethanol and diethyl ether, but insoluble in water. Spectroscopic analysis reported characteristic IR bands at 3380 cm‑1 (hydroxyl stretch), 1710 cm‑1 (carbonyl stretch), and 1605 cm‑1 (aryl C=C). The product shows a single sharp NMR signal for the aldehyde proton at 9.45 ppm and a downfield shift for the phenolic proton.

Preliminary biological assays suggested that fenoliformaldehydihartsissa exhibits low cytotoxicity to human fibroblast cultures, with an IC50 value >100 µM. No antimicrobial activity was detected in a standard panel of bacterial strains. The compound has not yet been evaluated for any industrial or pharmaceutical applications, and no patents have been filed. Because the data are limited to the initial discovery paper and no subsequent independent verification projects have been reported, fenoliformaldehydihartsissa remains a theoretical molecule within the chemoinformatics literature, with its potential properties largely unexplored.