FcRIn
FcRIn is a hypothetical intracellular adaptor protein that has been proposed to participate in signaling downstream of Fc receptors in immune cells. In the proposed model, FcRIn acts as a molecular bridge connecting activated Fc receptors to intracellular kinases and adaptor networks, thereby shaping responses such as phagocytosis and cytokine production. The precise molecular identity of FcRIn remains to be established, and different research groups have reported candidate proteins with varying domain architectures that could fulfill the proposed function.
Putative features of FcRIn include modular domains such as SH2-like motifs or other phosphotyrosine-binding regions that
Expression and interactions: Evidence for FcRIn comes mainly from in vitro studies and animal models. It is
Clinical relevance and research status: Because FcRIn is not yet definitively characterized, its physiological significance remains