Fabrys

Fabrys refers to people who bear the surname Fabry. The surname is of Germanic origin and has appeared across central and western Europe. In medical literature, the name is also associated with Fabry disease, an eponym linked to Johannes Fabry.

Johannes Fabry, a German-French physician, first described Fabry disease in 1898. The disease is an X-linked lysosomal storage disorder caused by deficiency of the enzyme alpha-galactosidase A, leading to the accumulation of globotriaosylceramide in multiple tissues and organs. Clinically, it can present with pain in the extremities, angiokeratomas, renal and cardiovascular involvement, and various ophthalmic findings. The condition is also known as Anderson–Fabry disease. Treatments have advanced to include enzyme replacement therapy and pharmacological chaperones, which can help manage symptoms and slow progression.

Beyond Fabry disease, the surname Fabry appears in historical and contemporary records across fields such as science, arts, and industry. However, no other individuals with the surname Fabry have achieved the same level of widespread prominence in standard reference works as Johannes Fabry does in the medical literature.