FZD1FZD10

FZD1FZD10 is a proposed gene fusion or transcript that would fuse portions of the FZD1 and FZD10 genes, both members of the Frizzled receptor family. The Frizzled receptors are seven-pass transmembrane proteins that bind Wnt ligands and initiate signaling through canonical (beta-catenin–dependent) and noncanonical pathways. If present, FZD1FZD10 could represent a chimeric form with altered receptor function and changes in Wnt signaling dynamics. The exact structure, breakpoints, and expression patterns of FZD1FZD10 have not been widely characterized, and reported instances are limited to specific studies or datasets.

Genomic context and potential function: FZD1 and FZD10 are paralogous members of the same gene family. A fusion event joining their coding sequences could yield a protein with mixed extracellular or intracellular domains, potentially affecting ligand affinity, receptor localization, or signaling output. The biological consequences would depend on the fusion breakpoint and whether the transcript remains in-frame.

Detection and status: Such fusions are typically detected by transcriptome sequencing (RNA-Seq) or genome sequencing in cancer genomics projects; findings require independent validation and functional assays to establish oncogenic relevance. At present, there is no widely accepted consensus on the prevalence or significance of FZD1FZD10.

See also: FZD1; FZD10; Frizzled receptors; Wnt signaling; Oncogenic gene fusions.