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FZD10

FZD10, or frizzled-10, is a member of the Frizzled family of Wnt receptors. Frizzled proteins are seven-pass transmembrane receptors characterized by an extracellular cysteine-rich domain that binds Wnt ligands. The FZD10 gene encodes a cell-surface receptor involved in transducing Wnt signals to intracellular pathways.

Function and signaling: FZD10 participates in Wnt signaling by engaging with Wnt ligands and co-receptors to

Expression and roles: FZD10 is expressed during embryonic development in tissues where Wnt signaling guides patterning

Clinical relevance: Dysregulation of Wnt signaling and Frizzled receptors has been implicated in diseases, including cancer.

Genetics and regulation: FZD10 is one of the vertebrate Frizzled genes, featuring the conserved structural domains

activate
downstream
pathways.
In
canonical
signaling,
it
can
promote
stabilization
of
β-catenin
and
transcription
of
Wnt
target
genes.
In
other
cellular
contexts,
it
can
also
participate
in
noncanonical
pathways
such
as
planar
cell
polarity
signaling.
The
exact
outcome
depends
on
the
ligand,
receptor
context,
and
intracellular
signaling
partners.
and
morphogenesis.
In
adult
tissues,
expression
is
more
limited
but
detected
in
specific
cell
types.
Through
Wnt
signaling,
FZD10
contributes
to
regulation
of
cell
fate,
proliferation,
differentiation,
and
tissue
organization.
FZD10
expression
has
been
observed
in
a
subset
of
tumors
and
is
under
investigation
as
a
potential
biomarker
and
therapeutic
target.
As
with
other
Wnt
pathway
components,
the
role
of
FZD10
is
context-dependent
and
an
active
area
of
research.
of
the
family.
Like
other
FZD
genes,
it
may
produce
multiple
transcript
variants
through
alternative
splicing.