FGF23independent

FGF23independent refers to a state or condition where the physiological effects or regulation of fibroblast growth factor 23 (FGF23) are not influenced by the hormone FGF23 itself. This concept is often discussed in the context of diseases or experimental models where certain cellular processes or molecular pathways are known to be regulated by FGF23. When these processes continue to function or are altered in a manner not attributable to the presence or absence of FGF23, they are described as FGF23independent.

This phenomenon can arise in several scenarios. For instance, in research, if a specific gene expression is upregulated but this change persists even after FGF23 signaling is blocked or absent, then that gene's regulation is considered FGF23independent. Similarly, in certain pathological conditions, the clinical manifestations or biochemical markers might be affected by factors other than FGF23. Identifying FGF23independent pathways is crucial for understanding the broader mechanisms underlying diseases and for developing targeted therapeutic strategies that are not reliant on modulating FGF23 activity. It helps to differentiate the direct impact of FGF23 from indirect effects or parallel signaling cascades that may contribute to a disease state.