FCGR1C

FCGR1C is a gene that encodes a protein belonging to the immunoglobulin G receptor family. This family of receptors plays a crucial role in the immune system by mediating the binding of immunoglobulin G (IgG) antibodies to various immune cells. The protein produced by FCGR1C is a high-affinity Fc gamma receptor, meaning it binds to IgG antibodies with strong affinity. This binding is essential for initiating a variety of immune responses.

The FCGR1C gene is located on chromosome 1. The protein it encodes is a transmembrane receptor that is expressed on the surface of certain immune cells, including macrophages, neutrophils, and mast cells. When IgG antibodies bind to their target antigens, the Fc portion of the antibody can then interact with Fc gamma receptors like the one produced by FCGR1C. This interaction triggers downstream signaling pathways within the immune cell, leading to effector functions such as phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and the release of inflammatory mediators.

Variations in the FCGR1C gene can potentially influence the efficiency of IgG-mediated immune responses. While the specific clinical implications of FCGR1C genetic variations are still an active area of research, understanding its function is important for comprehending immune system regulation and the development of immune-related diseases and therapies.