EphrinB4

EphrinB4 is a member of the ephrin-B subfamily of transmembrane ligands. These proteins play crucial roles in cell-cell communication, particularly in developmental processes and tissue homeostasis. EphrinB4 interacts with Eph receptors, specifically EphB receptors, to mediate a variety of cellular responses. The binding of ephrinB4 to its Eph receptor triggers bidirectional signaling, meaning it activates signaling pathways in both the cell expressing the ephrinB4 ligand and the cell expressing the Eph receptor.

In developmental biology, ephrinB4 and its receptors are involved in processes such as neuronal development, including axon guidance and the formation of synaptic connections. They also contribute to vascular development, influencing the formation and patterning of blood vessels. Beyond development, ephrinB4 has been implicated in immune cell trafficking and function, as well as in the regulation of cell adhesion and migration in various tissues. Aberrant ephrinB4 signaling has been linked to certain diseases, including some forms of cancer, where it can contribute to tumor growth and metastasis. Research into ephrinB4 continues to uncover its diverse roles in both normal physiological processes and pathological conditions.