EphrinB
Ephrin-B refers to a family of membrane-anchored ligands for Eph receptor tyrosine kinases, encoded in humans by EFNB1, EFNB2, and EFNB3. These transmembrane ligands engage Eph receptors on neighboring cells to initiate bidirectional signaling, enabling communication between adjacent cells during development and in adult tissues.
Structure and expression: Each ephrin-B protein contains a single transmembrane domain and a cytoplasmic tail with
Signaling: Binding to Eph receptors triggers forward signaling in the Eph-expressing cell and reverse signaling into
Biological roles: Ephrin-B signaling governs axon guidance, synapse formation, and neural crest cell migration, as well
Clinical significance: Mutations in EFNB1 cause craniofrontonasal syndrome, a disorder of craniofacial development linked to altered