EP3

EP3 is an acronym that can denote multiple concepts across different domains. In scientific literature, it most often refers to prostaglandin E receptor 3, a member of the EP receptor family.

Prostaglandin E receptor 3 (EP3) is a G protein-coupled receptor that binds prostaglandin E2 (PGE2). It is encoded by the PTGER3 gene in humans and exists in several splice variants, yielding receptors with differing signaling properties. The receptor classically couples to Gi proteins, inhibiting adenylyl cyclase and lowering cAMP levels, though some isoforms can also engage other G proteins in a tissue-dependent manner. EP3 is expressed in various tissues, including the nervous system, gastrointestinal tract, and vasculature, where it participates in processes such as thermoregulation, gastric mucosal protection, platelet function, and inflammatory responses.

Physiological and pathological roles: The EP3 signaling axis contributes to fever and pain responses, uterine contraction, and regulation of blood flow. Due to its diverse actions, EP3 is a focus in research on inflammatory diseases, obesity-related metabolism, and cancer. Pharmacological manipulation of EP3 with agonists or antagonists is explored for potential benefits in pain relief and anti-inflammatory therapy, though clinical applications require careful targeting due to tissue-specific effects.

Other uses: In non-scientific contexts, EP3 is sometimes used to denote Episode 3 of a TV series, podcast, or other serialized media, or as a short form in product catalogs and documentation. Without context, "EP3" remains ambiguous, underscoring the importance of domain-specific clarification.