EIF2AK4
EIF2AK4, also known as GCN2, is a gene that encodes a protein kinase. This protein is a key regulator of the integrated stress response in eukaryotic cells. The integrated stress response is a cellular mechanism that helps cells cope with various stress conditions, such as nutrient deprivation, viral infection, or the accumulation of misfolded proteins.
The EIF2AK4 protein acts by phosphorylating the alpha subunit of eukaryotic initiation factor 2 (eIF2α). Phosphorylation
Mutations in the EIF2AK4 gene have been associated with certain human diseases. Notably, biallelic loss-of-function mutations