EGFRsignaali
EGFRsignaali refers to the signaling pathway mediated by the Epidermal Growth Factor Receptor (EGFR). EGFR is a transmembrane protein that acts as a receptor for epidermal growth factors, such as EGF and transforming growth factor-alpha (TGF-α). Upon binding of these ligands, EGFR dimerizes and activates its intrinsic tyrosine kinase domain. This activation triggers a cascade of intracellular signaling events.
The activated EGFR recruits adapter proteins, which in turn activate downstream signaling molecules like Ras, Raf,
Dysregulation of EGFR signaling is implicated in the development and progression of various human diseases, most