EFCAB9

EFCAB9, or EF-hand calcium-binding domain-containing protein 9, is a human protein encoded by the EFCAB9 gene. The EFCAB family comprises small, cytosolic proteins that contain EF-hand motifs, a canonical calcium-binding helix–loop–helix structure. EFCAB9 is predicted to share this architecture and to participate in calcium-dependent signaling pathways, although the precise molecular function of this particular family member remains to be fully defined.

In terms of genetics and evolution, EFCAB9 is conserved across vertebrates, with orthologs identified in multiple species, suggesting a conserved physiological role. The expression pattern of EFCAB9 in human tissues has been detected in transcriptome data, though tissue-specific abundance and regulation under physiological conditions are not comprehensively characterized. As of current knowledge, there are no widely established disease associations linked to EFCAB9, and its contribution to human biology is primarily inferred from its domain composition and evolutionary conservation.

Research efforts continue to determine the protein’s subcellular localization, interaction partners, and involvement in calcium signaling networks. Determining whether EFCAB9 participates in specific complexes or modulates particular enzymes or channels will clarify its role in cellular homeostasis and physiology. Further experimental work, including localization studies, interaction assays, and functional analyses, is needed to define its exact function and relevance to health and disease.