EDNRA
EDNRA, or endothelin receptor type A, is a human gene that encodes the endothelin receptor type A (ET_A), a G protein-coupled receptor. Its primary ligands are endothelin-1, endothelin-2, and endothelin-3, with endothelin-1 showing the highest affinity for ET_A. The receptor is expressed in vascular smooth muscle cells and certain neurons, where it mediates endothelin-1–induced vasoconstriction and contributes to vascular remodeling and proliferation.
ET_A is a seven-transmembrane-domain GPCR that signals mainly through Gq/11 proteins. Upon ligand binding, phospholipase C
Physiological roles of EDNRA signaling include regulation of vascular tone and blood pressure, with particular importance
Clinical relevance of EDNRA signaling is seen in diseases characterized by excessive vasoconstriction and vascular remodeling,
EDNRA belongs to the endothelin receptor family within the broader class of G protein-coupled receptors. The