E2type
E2type is a term used in biochemistry and molecular biology to refer to the class of enzymes known as E2 ubiquitin-conjugating enzymes, a component of the ubiquitin-proteasome system. In many sources the phrase E2-type is informal; the standard nomenclature identifies these proteins as E2 enzymes (UBE2 family). The term is sometimes used in teaching materials or reviews to distinguish E2 enzymes from E3 ligases and E1 activating enzymes.
E2 enzymes play a central role in ubiquitination, a process that attaches ubiquitin molecules to substrates
Most E2 enzymes are small cytosolic proteins, typically around 15–25 kDa, with a catalytic cysteine that forms
Dysregulation of E2 activity has been linked to diseases such as cancer and neurodegeneration, making E2-type
See also: Ubiquitin-proteasome system, E1 activating enzymes, E3 ligases.