DtxR
DtxR, short for diphtheria toxin repressor, is a metal-dependent transcriptional regulator found in Corynebacterium diphtheriae and related Corynebacterium species. It functions as a global regulator of iron homeostasis and virulence gene expression, including repression of the diphtheria toxin (tox) gene when iron is abundant. The DtxR protein is encoded by the chromosomal dtxR gene and acts by binding specific DNA sequences known as DtxR boxes in the promoters of target genes.
Mechanism and regulation: DtxR activity depends on binding divalent metal ions, most notably Fe2+. In iron-replete
Structure and family: DtxR belongs to the DtxR family of metal-dependent transcriptional regulators. It typically forms
Regulatory scope and significance: In addition to the tox operon, DtxR controls a broad set of genes