DoseCl

DoseCl is a cross-platform open-source framework and library for calculating medical dosages. It is designed to assist clinicians, researchers, and health IT developers by providing configurable dosing algorithms, unit handling, and safety checks. The project emphasizes transparency, reproducibility, and extensibility through a modular architecture.

The core of DoseCl is a calculation engine that accepts patient data such as age, weight, height, renal function, hepatic function, and disease states, and returns dose recommendations based on published guidelines, patient-specific modifiers, and predefined rule sets. It supports pediatric and adult dosing, dose rounding policies, and unit conversions, and includes validation routines to flag potential dosing anomalies.

A key feature is its data and guidelines layer, which stores pharmacokinetic parameters, dosing regimens, and therapeutic windows. Users can extend this layer with custom guideline sets or locally approved protocols. DoseCl also exposes a plugin interface for integration with electronic health records and clinical decision support systems, including REST and language bindings for Python and JavaScript.

The project is typically distributed under an open-source license and maintained by a community of contributors. It emphasizes documentation, testing, and reproducibility, with example workflows and reference datasets to enable evaluation and benchmarking.

In practice, DoseCl is intended to support, not replace, clinical judgment. Pharmacists and physicians should verify all recommendations in the context of the patient and local guidelines, and DoseCl should undergo institutional validation before deployment.