DoseAUC0

DoseAUC0 is not a standard, widely recognized term in pharmacokinetics. In practice, it may appear as a variable name or shorthand in datasets or modeling scripts to refer to either a dose-normalized AUC metric or a product involving dose, depending on the context. The most common related concept is AUC, the area under the concentration–time curve, which quantifies overall drug exposure after administration. AUC0-t denotes exposure from time zero to a specified time t, while AUC0-∞ extends to infinity. Dose-normalized AUC refers to AUC divided by the administered dose, often written as AUC0-t / Dose or AUC0-∞ / Dose. This normalization facilitates comparison of exposure across dose levels, formulations, or subjects, assuming linear pharmacokinetics.

Calculation: AUC is typically estimated from concentration–time data using methods such as the trapezoidal rule. Once AUC0-t is obtained, dose-normalized AUC is computed by dividing by the dose (with units such as ng·h/mL per mg). If a model uses DoseAUC0 as a product, the interpretation would depend on the context and the equation in use.

Applications: DoseAUC0-like metrics are used in bioequivalence analyses, dose-ranging studies, and population pharmacokinetics to compare exposure, guide dosing, and assess linearity and bioavailability.

Limitations: Dose-normalized AUC assumes linear pharmacokinetics; enzymatic saturation, saturable transport, or nonlinear clearance can invalidate proportional relationships. In such cases, DoseAUC0 may not reliably reflect exposure changes with dose.