DiphosphateriboseNAD

DiphosphateriboseNAD, often abbreviated as P2RiboseNAD or sometimes referred to as cyclic ADP-ribose (cADPR) without the phosphorus, is a signaling molecule involved in cellular processes. It is structurally related to nicotinamide adenine dinucleotide (NAD+). Specifically, diphosphateriboseNAD is formed from NAD+ through enzymatic action, typically by ADP-ribosyl cyclases. This molecule plays a role in calcium signaling, acting as an intracellular messenger that can trigger the release of calcium from intracellular stores, such as the endoplasmic reticulum. The precise mechanisms and full range of biological functions attributed to diphosphateriboseNAD are still areas of ongoing research. Its presence and activity are observed in various cell types and have been implicated in processes like muscle contraction and neurotransmitter release. While closely related to cADPR, the presence of the additional phosphate group in diphosphateriboseNAD is a key distinguishing feature that may influence its receptor binding and downstream signaling pathways.