Dezellulierte

Dezellulierte is a term of German origin, literally translating to "delayered" or "stripped of its layers." In a technical or scientific context, it often refers to a process or state where cellular material or tissue has had its cellular components removed. This can be achieved through various methods, such as chemical treatments, physical disruption, or biological processes. The resulting material is often referred to as decellularized extracellular matrix (dECM).

Decellularized tissues are of significant interest in regenerative medicine and tissue engineering. By removing the cells, the underlying extracellular matrix structure is preserved. This matrix provides a natural scaffold that can guide cell growth, differentiation, and tissue formation. Decellularized tissues can be derived from a variety of sources, including skin, cartilage, bone, and even whole organs like the heart or lungs.

The process of decellularization aims to eliminate immunogenicity by removing all cellular material, including DNA and proteins, that could trigger an immune response in a recipient. This makes decellularized scaffolds a promising biomaterial for creating functional tissue replacements and for drug screening. The remaining acellular matrix retains the complex architecture and biochemical cues of the original tissue, offering a more biocompatible and effective environment for the repopulation of new cells and the regeneration of functional tissue. Research continues to refine decellularization techniques to ensure complete cell removal while preserving the integrity and bioactivity of the extracellular matrix.