Deazaguanosinecontaining

Deazaguanosinecontaining refers to nucleosides or nucleic acids that incorporate a deazaguanosine moiety. Deazaguanosine is a modified guanosine analog where one or more nitrogen atoms in the purine ring are replaced by carbon atoms. Specifically, in the most common form, the nitrogen at position 7 is replaced by a carbon atom, resulting in 7-deazaguanosine. This structural alteration can significantly impact the base-pairing properties, metabolic fate, and biological activity of the resulting nucleoside or nucleic acid.

Incorporating deazaguanosine into DNA or RNA can lead to changes in their physical and chemical characteristics. For instance, 7-deazaguanosine-containing DNA can exhibit altered melting temperatures and may be more resistant to certain enzymatic modifications. In oligonucleotide synthesis, the introduction of deazaguanosine can affect hybridization efficiency and stability. These modified nucleic acids have found applications in various fields, including molecular biology research, diagnostics, and therapeutics.

Research into deazaguanosine analogs has explored their potential as antiviral or anticancer agents. The altered structure can sometimes interfere with viral replication or cancer cell proliferation mechanisms. Furthermore, deazaguanosine derivatives are utilized in sequencing technologies and as probes in molecular hybridization assays where their unique properties offer advantages over standard guanosine-containing molecules. The term "deazaguanosinecontaining" broadly encompasses any biological or synthetic molecule where this modified nucleoside is a constituent part, highlighting its presence and potential functional implications.