DSBR
DSBR stands for double-strand break repair, the set of cellular mechanisms that restore DNA when both strands of the double helix are broken. In genetics, DSBR is often discussed as the double-strand break repair model of homologous recombination, a framework for understanding how meiotic crossovers and genome maintenance are accomplished by using an intact homologous sequence as a template.
The DSBR model describes a canonical sequence of events after a DNA double-strand break is detected. Nuclease
DSBR is contrasted with other repair pathways, notably synthesis-dependent strand annealing (SDSA), which typically produces non-crossovers
Significance and clinical relevance stem from the role of homologous recombination in DSBR. Components such as