DNAbindingsspesifisitet
DNAbindingsspesifisitet refers to the specificity of a protein's interaction with DNA. This specificity is crucial for various cellular processes, including DNA replication, transcription, and repair.
Proteins that interact with DNA, such as transcription factors and DNA-binding proteins, possess specific domains that
The specificity of a protein's DNA-binding is typically described using measures such as the dissociation constant
The sequence-specificity of DNA-binding proteins is a result of non-covalent interactions between the protein's binding site
Elevated specificity is beneficial for efficient gene expression, as it reduces the likelihood of non-specific interactions
Studies on the molecular determinants of protein-DNA specificity have advanced our understanding of the relationships between