DKK3

DKK3, also known as Dickkopf-3, is a secreted protein that belongs to the Dickkopf family of Wnt signaling inhibitors. These proteins are characterized by the presence of two conserved cysteine-rich domains. DKK3 plays a role in various biological processes, including embryonic development, cell proliferation, and differentiation. Its precise functions can be context-dependent, varying across different cell types and developmental stages.

Research suggests that DKK3 can act as a tumor suppressor in certain cancers, inhibiting tumor growth and progression. Conversely, in other contexts, it has been implicated in promoting tumor cell survival or invasion. This dual role highlights the complexity of DKK3's involvement in disease. The regulation of DKK3 expression is also a subject of study, with evidence pointing to epigenetic modifications and transcriptional factors influencing its levels. Understanding the intricate mechanisms by which DKK3 operates is crucial for its potential therapeutic applications.