DIS1

DIS1 refers to the gene encoding the Disrupted in Schizophrenia 1 protein. This protein is a crucial scaffolding molecule involved in the development and function of the brain. It plays a significant role in neuronal development, including neurite outgrowth, synapse formation, and the regulation of neurotransmitter release. DIS1 is known to interact with a variety of other proteins, forming complexes that modulate intracellular signaling pathways essential for neuronal connectivity.

Mutations or variations in the DIS1 gene have been associated with an increased risk of developing schizophrenia and other psychiatric disorders. Research suggests that these genetic alterations can disrupt normal brain development and synaptic function, potentially contributing to the pathophysiology of these conditions. While the exact mechanisms are still being investigated, DIS1's role in neuronal plasticity and signaling makes it a key player in understanding the genetic underpinnings of mental health disorders. The protein's diverse cellular functions highlight its importance in maintaining neurological health.