DCTN3

DCTN3, also known as Dynactin Subunit 3, is a protein encoded by the DCTN3 gene in humans. It is a component of the dynactin complex, a multi-subunit assembly that plays a crucial role in intracellular motility processes, including retrograde transport along microtubules. The dynactin complex acts as an adaptor for the motor protein dynein, facilitating the movement of organelles, vesicles, and other cellular cargoes within the cell.

The DCTN3 gene is located on chromosome 2q37. Its protein product, DCTN3, is involved in maintaining the structural integrity of the dynactin complex and contributing to its function in cellular transport mechanisms. The protein consists of several domains that facilitate interactions with other dynactin components and dynein.

Research indicates that alterations in the expression or function of DCTN3 may impact cellular trafficking and are being explored in the context of neurodegenerative diseases, cancer, and other disorders associated with disrupted intracellular transport. However, the precise molecular mechanisms and clinical implications of DCTN3 variability remain under active investigation.

Overall, DCTN3 is considered an essential component of the cellular machinery responsible for intracellular organization and movement, contributing to various physiological processes critical to cell survival and function.