Collagenlike
Collagenlike refers to proteins or peptide sequences that resemble collagen in structure and motif, particularly the capacity to form a collagen-like triple helix. The defining feature is a repeating Gly-X-Y sequence that promotes the assembly of three polypeptide chains into a tight, triple-stranded structure. In native collagen, X and Y are often proline and hydroxyproline, the latter resulting from post-translational modification; many collagenlike constructs mimic this motif with hydroxyproline or substitutes chosen to tune stability. The resulting triple helix may be soluble or assemble into higher-order fibrils or networks under suitable conditions.
Occurrence and production: Collagenlike sequences appear in some natural proteins, including certain bacterial adhesins and archaeal
Properties and applications: The stability of collagenlike triple helices depends on sequence, length, and environment (temperature,
Differences from native collagen: Collagenlike materials may lack the full post-translational modification repertoire and cross-linking patterns