CoRESTLSD1HDAC

CoRESTLSD1HDAC refers to a multiprotein complex involved in epigenetic regulation. This complex integrates the activities of several key proteins: CoREST (Co-Repressor of REST), LSD1 (Lysine-Specific Demethylase 1), and HDACs (Histone Deacetylases). CoREST acts as a scaffolding protein, bringing together LSD1 and HDACs. LSD1 is a histone demethylase that specifically removes methyl groups from mono- and dimethylated lysine 4 on histone H3 (H3K4me1 and H3K4me2), marks typically associated with active gene transcription. HDACs, on the other hand, remove acetyl groups from histones, generally leading to chromatin condensation and gene silencing. The CoRESTLSD1HDAC complex thus functions as a powerful repressor of gene expression. It is particularly known for its role in repressing neuronal genes in non-neuronal cells, mediated by the transcription factor REST (RE-1 Silencing Transcription Factor). Beyond neuronal gene silencing, the complex has been implicated in various cellular processes including cell differentiation, development, and cancer. Dysregulation of this complex can contribute to disease states, making it a target of therapeutic interest.