ClpCP
ClpCP refers to a proteolytic system formed by the ClpP protease core and the ClpC ATPase chaperone. In many bacteria and in some organelles, ClpP provides the proteolytic core, while ClpC uses ATP hydrolysis to recognize, unfold, and translocate substrates into ClpP for degradation. The overall activity of ClpCP is driven by energy from ATP and is tightly regulated by adaptor proteins that determine which proteins are delivered to the complex.
Substrate recognition often relies on adaptor proteins that bind specific targets and present them to the
Distribution and significance: ClpCP-type proteases are widespread in bacteria, particularly among Gram-positive species. In eukaryotic organelles,
Function and role: ClpCP contributes to protein quality control by removing misfolded or damaged proteins and