Clb1Clb2
Clb1Clb2 refers to the mitotic cyclin–CDK complex formed in budding yeast by the association of the core cyclin-dependent kinase Cdc28 with the B-type cyclins Clb1 and Clb2. These cyclins activate Cdc28 to drive the G2–M transition and are essential for progression through mitosis. Clb1 and Clb2 are highly similar and largely redundant in function; strains lacking only CLB1 or CLB2 show mild or conditional defects, whereas simultaneous loss of both is lethal, underscoring their overlapping roles in promoting mitotic entry and ensuring proper mitotic progression.
During the cell cycle, Clb1/Clb2–Cdc28 activity promotes key mitotic events, including entry into mitosis, spindle formation
In yeast genetics and cell biology, Clb1Clb2 serves as a model for redundant B-type cyclins and their