Cisplatinrelated

Cisplatinrelated refers to adverse effects, complications, or other outcomes associated with the use of cisplatin. Cisplatin is a chemotherapy drug widely used in the treatment of various cancers, including testicular, ovarian, bladder, lung, and head and neck cancers. Its mechanism of action involves binding to DNA, forming cross-links that inhibit DNA replication and transcription, ultimately leading to cancer cell death.

However, like many potent chemotherapeutic agents, cisplatin can also damage healthy cells, resulting in a range of side effects. The most common cisplatinrelated side effects include nephrotoxicity (kidney damage), neurotoxicity (nerve damage, often manifesting as peripheral neuropathy), ototoxicity (hearing damage, leading to tinnitus or hearing loss), and myelosuppression (bone marrow suppression, causing reduced blood cell counts). Nausea and vomiting are also very common, though often manageable with antiemetic medications.

Management strategies for cisplatinrelated toxicity are crucial for patient care. This includes careful dosing, hydration before and after administration to protect the kidneys, and monitoring of kidney and liver function, hearing, and blood counts. Awareness of cisplatinrelated symptoms allows for early intervention, potentially mitigating the severity of side effects and improving treatment tolerance. Research continues to explore ways to minimize cisplatinrelated toxicities while maintaining its efficacy in cancer treatment.