Chlorprothixene

Chlorprothixene is an antipsychotic medication belonging to the thioxanthene class. It is primarily used in the treatment of schizophrenia and other psychotic disorders. It is also sometimes prescribed for anxiety and agitation, particularly in elderly patients.

The mechanism of action of chlorprothixene involves blocking dopamine receptors in the brain, specifically D1 and D2 receptors. It also has significant effects on serotonin receptors, as well as histamine and alpha-adrenergic receptors. This broad receptor blockade contributes to its antipsychotic and sedative properties.

Chlorprothixene is administered orally. The dosage and duration of treatment are determined by the individual patient's response and the severity of their symptoms. Like other antipsychotics, it may take several weeks to observe the full therapeutic effect.

Common side effects of chlorprothixene can include drowsiness, dry mouth, blurred vision, and constipation. More serious side effects, though less common, can include extrapyramidal symptoms (movement disorders), such as tremors and rigidity, and a potentially life-threatening condition called neuroleptic malignant syndrome.

Chlorprothixene is not approved for use in all countries. Its use should be carefully monitored by a healthcare professional due to potential side effects and drug interactions. It is generally not recommended during pregnancy or breastfeeding.