Carnitinemediated
Carnitinemediated describes biochemical processes that require or are facilitated by carnitine, a quaternary amine essential for the transport and metabolism of long-chain fatty acids. The best-known example is the carnitine shuttle, which enables mitochondrial beta-oxidation of long-chain acyl groups and thus cellular energy production, especially during fasting or sustained exercise.
In mammals, the shuttle involves three steps. First, carnitine palmitoyltransferase I (CPT I) on the outer mitochondrial
Physiological and clinical relevance includes its role in energy homeostasis and metabolic flexibility. Defects in carnitine
The term carnitinemediated is commonly used to denote processes driven by carnitine, with the carnitine shuttle