Cadherinegenen

Cadherinegenen is a protein-coding gene located on chromosome 16 in humans. It is a member of the cadherin superfamily, which includes proteins that play crucial roles in cell-cell adhesion. The cadherinegenen gene encodes a protein called cadherinegenen, which is a type I transmembrane protein. This protein is involved in the formation of adherens junctions, which are critical for maintaining cell polarity and tissue integrity.

Cadherinegenen is expressed in various tissues, including the brain, heart, and muscle. Its expression is regulated by various signaling pathways, including the Wnt and Notch pathways. Mutations in the cadherinegenen gene have been associated with several diseases, including autism spectrum disorder and intellectual disability. These mutations can lead to abnormal cell adhesion, which can disrupt normal brain development and function.

The cadherinegenen protein is a homophilic adhesion molecule, meaning it interacts with other cadherinegenen proteins on adjacent cells. This interaction is mediated by the extracellular domain of the protein, which contains a series of cadherin repeats. The intracellular domain of the protein is involved in signaling, and it interacts with various proteins, including catenins and actin.

In summary, cadherinegenen is a protein-coding gene that encodes a type I transmembrane protein involved in cell-cell adhesion. It is expressed in various tissues and is regulated by several signaling pathways. Mutations in the cadherinegenen gene have been associated with several diseases, including autism spectrum disorder and intellectual disability.