CTCFDNA

CTCFDNA refers to the DNA sequences that are bound by the CTCF protein. CTCF (CCCTC-binding factor) is a highly conserved, multifunctional zinc-finger protein that plays a critical role in genome organization and regulation. It acts as a transcriptional repressor and activator, insulator, and chromatin boundary element. CTCF is known to bind to specific DNA sequences, often called CTCF sites or motifs, which are recognized by its zinc-finger domains. These binding events are crucial for establishing the three-dimensional architecture of the genome, including the formation of chromatin loops and the segregation of active and inactive genomic regions. The distribution and binding patterns of CTCF are dynamic and can be influenced by various cellular processes and epigenetic modifications. Identifying CTCFDNA is important for understanding gene regulation, genome stability, and developmental processes. Techniques such as Chromatin Immunoprecipitation sequencing (ChIP-seq) are commonly used to map CTCF binding sites genome-wide, providing insights into CTCFDNA.